Spasmolytic Activity of Methyl Angolensate : a Triterpenoid Isolated from Entandrophragma angolense
スポンサーリンク
概要
- 論文の詳細を見る
Entandrophragma angolense is a medicinal plant used in folk medicine against several diseases including peptic ulcer. Methyl angolensate was isolated from E.angolense by recrystallization from methanol. The needle-like crystals were characterized and tested on isolated rabbit jejunum, guinea pig ileum and the rat fundus strip. The compound was also evaluated on the gastrointestinal transit in mice. The results showed that the compound exerted significant concentration dependent inhibition of smooth muscle and reduced the propulsive action of the gastrointestinal tract in mice. The relaxation observed did not attenuate acetylcholine and histamine induced contractions, but was found to inhibit contractions induced by serotonin. It is therefore suggested that methyl angolensate may exert its activity on gastrointestinal smooth muscle via serotonergic mechanisms.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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Emeje Martins
Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharma
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Emeje Martins
Department Of Pharmacology And Toxicology University Of Ibadan
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Emeje Martins
ナイジェリア
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Amos Samson
Department Of Pharmacology And Toxicology National Institute For Pharmaceutical Research And Develop
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ORISADIPE Abayomi
Department of Medicinal Plant Research and Traditional Medicine, University of Ibadan
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ADESOMOJU Akinbobola
National Institute for Pharmaceutical Research and Development, Department of Chemistry, University
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BINDA Lucy
Department of Pharmacology and Toxicology, University of Ibadan
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OKOGUN Joseph
Department of Medicinal Plant Research and Traditional Medicine, University of Ibadan
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WAMBEBE Charles
Department of Pharmacology and Toxicology, University of Ibadan
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GAMANIEL Karniyus
Department of Pharmacology and Toxicology, University of Ibadan
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Binda Lucy
Department Of Pharmacology And Toxicology National Institute For Pharmaceutical Research And Develop
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Okogun Joseph
Department Of Medicinal Plant Research And Traditional Medicine University Of Ibadan
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Wambebe Charles
Department Of Pharmacology And Toxicology National Institute For Pharmaceutical Research And Develop
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Gamaniel Karniyus
Department Of Pharmacology And Toxicology National Institute For Pharmaceutical Research And Develop
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Orisadipe Abayomi
Department Of Medicinal Plant Research And Traditional Medicine University Of Ibadan
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Adesomoju Akinbobola
National Institute For Pharmaceutical Research And Development Department Of Chemistry University Of
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