Effects of Paint Thinner Exposure on Serum LH, FSH and Testosterone Levels and Hypothalamic Catecholamine Contents in the Male Rat

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概要

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• We have investigated the effects of thinner inhalation on serum LH, FSH and testosterone levels tohether with changes in hypothalamic catecholaminergic system in the male rat. A control group inhaled normal air ventilation. The remaining animals were divided into two groups and exposed to paint thinner in a glassy cage for 15 or 30 d. Toluene concentration (the largest constituent in thinner, 66%) was set at 3000 ppm in the inhalation air. At the end, all animals were decapitated and blood samples obtained. Serum LH and FSH levels were measured by RIA and testosterone by enzyme immunoassay. Following removal of brains on dry ice, medial preptic area, suprachiasmatic nucleus, median eminence and arcuate nucleus were isolated by micropunch technique. Noradrenaline, 3, 4-dihydroxyphenylglycol (DHPG) and dopamine concentrations of these hypothalamic areas were determined by HPLC-ECD. Fifteen-day thinner inhalation significantly suppressed serum LH and testosterone levels in parallel (p<0.001) compared to control group values (LH:0.77±0.07;testosterone:2.67±0.39). Thirtyday exposure markedly dereased LH levels (p<0.001), but surprisingly had no significant effect on testosterone. Serum FSH levels were not significantly altered in either group. Thinner inhalation for 15 or 30 d did not cause any significant change in noradrenaline, DHPG or dopamine concentrations in the hypothalamic regions examined (except in the arcuate nucleus). These results suggest that paint thinner has an anti-gonadotropic effect and may cause long-term endocrine disturbances in the male. It is thought that the hypothalamic catecholaminergic system is not involved in thinner inhibition of LH and testosterone secretion.

• 公益社団法人日本薬学会の論文
• 2001-02-01

著者

• Kutlu Selim

  First University Medical School Department Of Physiology

• Yilmaz Bayram

  First University Medical School Department Of Physiology

• Canpolat Sinan

  First University Medical School Department Of Physiology

• SANDAL Suleyman

  First University Medical School, Department of Physiology

• AYAR Ahmet

  First University Medical School, Pharmacology

• MOGULKOC Rasim

  First University Medical School, Department of Physiology

• KELESTIMUR Haluk

  First University Medical School, Department of Physiology

• Ayar Ahmet

  First University Medical School Pharmacology

• Mogulkoc Rasim

  First University Medical School Department Of Physiology

• Sandal Suleyman

  First University Medical School Department Of Physiology

• Kelestimur Haluk

  First University Medical School Department Of Physiology

関連論文

• Endocrine Disruptive Effects of Polychlorinated Biphenyls on the Thyroid Gland in Female Rats
• Effects of Paint Thinner Exposure on Serum LH, FSH and Testosterone Levels and Hypothalamic Catecholamine Contents in the Male Rat

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