Relative Hypoglycemic Effect of Insulin Suppositories in Diabetic Beagle Dogs : Optimization of Various Concentrations of Sodium Salicylate and Polyoxyethylene-9-lauryl Ether

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of insulin suppositories containing different amounts and concentrations of sodium salicylate (50, 100mg) and polyoxyethylene-9-lauryl ether (POELE 1, 3, 4%), respectively, on the plasma glucose concentration of diabetic beagle dogs was investigated after rectal administration. Comparison of the effects of these formulations was made with that produced after subcutaneous insulin injections. Insulin suppositories containing sodium salicylate (50mg) produced a maximum reduction of plasma glucose concentration (C_<max>) of 55±11%, an area under the curve (AUC) of 252±59% reduction h; and a relative hypoglycemia (RH) of 49±12% relative to subcutaneous injection of insulin (4U/kg). Increasing sodium salicylate to 100mg/suppository did not improve the hypoglycemic effect of insulin suppositories further. Investigation of the influence of insulin suppositories containing different concentrations of the nonionic surfactant POELE (1, 3, 4%) showed that; the suppositories containing the lowest concentration (1%) produced the highest hypoglycemic effect with a C_<max> of 68%, AUC of 332±67% reduction h, and RH of 55±11%. Incorporation of sodium salicylate 50mg in insulin suppositories containing 1% POELE did not improve further the effects found with these suppositories. In conclusion, a relative hypoglycemic effect of about 50-55% can be achieved using insulin suppositories containing Witepsol W35 as a base, insulin (5U/kg), and sodium salicylate (50mg) or POELE (1%) as rectal absorption enhancers.

• 公益社団法人日本薬学会の論文
• 2001-11-01

著者

• Al-shora Hasan

  Departments Of Pharmaceutics College Of Pharmacy King Saud University

• AHMED HOSNY

  Departments of Pharmaceutics, College of Pharmacy, King Saud University

• MOHEY ALDIN

  Departments of Pharmacology, College of Pharmacy, King Saud University

• Ahmed Hosny

  Departments Of Pharmaceutics College Of Pharmacy King Saud University

• Hosny Ehab

  Department Of Pharmaceutics

• Mohey Aldin

  Departments Of Pharmacology College Of Pharmacy King Saud University

• Elmazar Mohamad

  Departments of Pharmacology, College of Pharmacy, King Saud University

関連論文

• Relative Hypoglycemic Effect of Insulin Suppositories in Diabetic Beagle Dogs : Optimization of Various Concentrations of Sodium Salicylate and Polyoxyethylene-9-lauryl Ether

スポンサーリンク