EFFECTS OF DILTIAZEM ON PLASMA AND TISSUE DIGOXIN LEVELS IN MICE
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概要
- 論文の詳細を見る
Effects of diltiazem hydrochloride (DTZ) on digoxin (DX) concentrations in plasma and tissues (brain, heart, liver, and kidney) were studied in mice, and the effects were compared with those of quinidine sulfate (QD). When DX (0.2 mg/kg) was coadministered with DTZ (60 mg/kg) orally for 5 d to mice, plasma DX concentrations were increased significantly as with QD (100 mg/kg). Tissue DX concentrations were also increased in brain, heart, and liver. However, the DX tissue/plasma concentration (T/P) rations for brain, heart, and kidney were rather decreased with DTZ or QD. The increased plasma and tissue DX concentratios and the decreased T/P ratios with DTZ might be responsible for both the displacement of tissue DX binding and reduced DX elimination as with QD.
- 公益社団法人日本薬学会の論文
著者
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OWADA Eiji
Hokkaido College of Pharmacy
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ITO Keiji
Hokkaido College of Pharmacy
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YOSHIDA Akiko
Hokkaido Institute of Pharmaceutical Sciences
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Yoshida Akiko
Hokkaido Institute Of Pharmaceutical Sciences:departments Of Pharmacy And Neuropsychiatry
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Owada E
Hokkaido Inst. Pharmaceutical Sciences
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FUJITA MASATSUGU
Hokkaido Institute of Pharmaceutical Sciences
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Yoshida Akiko
Nagoya Univ. Nagoya Jpn
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Owada Eiji
Hokkaido Institute Of Pharmaceutical Sciences
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Ito Keiji
Department Of Pediatrics Hokkaido Children's Hospital And Medical Center
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