EFFECT OF TEI-4120 (3-BENZOYL-N-β-ETHOXYISOPROPYL-2-METHLINDOLE) ON CARRAGEENAN INDUCED DISSEMINATED INTRAVASCULAR COAGULATION (DIC) IN RATS

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In order to evaluate TEI-4120 (3-benzoyl-N-β-ethoxyisopropyl-2-methylindole), as a possible therapheutic compound to disseminated intravascular coagulation(DIC), DIC model in rats was induced by the treatment of λ-carrageenan according to the method of sugiyama et al. with minor modification. Two hours after intraperitoneal injection of λ-carrageenan, plasma fibrinogen decreased and platelet count, prothrombin time, serial thrombin time and plasma TXB_2 prolonged or increased. By use of this model, the activities of TEI-4120,new antithrombotic compound, was evaluated compared with three other compounds, aspirin, warfarin and heparin. As a result, TEI-4120 is effective in this model. Combination theraphy of TEI-4120 and warfarin is more effective than single administration of TEI-4120. The effect of combination theraphy of TEI-4120 and warfarin is consistene with that of heparin. The above result suggests that TEI-4120 seems to be a promissing compound to the theraphy of DIC.
公益社団法人日本薬学会の論文