METHYLPREDNISOLONE REDUCES THE NEPHROTOXICITY CAUSED BY CISPLATIN
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概要
- 論文の詳細を見る
Male Sprague-Dawley rats were given either 6.5 or 8.5 mg/kg of iv cisplatin combined with three injections of sc methylprednisolone in doses of either 50,100 or 250 mg/kg at -4,0 and 4 h after the cisplatin injection. Blood urea nitrogen and serum creatinine levels were determined on day 5 following the cisplatin injection. The protective effects of methylprednisolone on cisplatininduced nephrotoxicity were clearly demonstrated. Our preliminary results suggest that a much higher dose of cisplatin could be injected in cancer chemotherapy, if it was combined with methylprednisolone.
- 公益社団法人日本薬学会の論文
著者
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Ueda Toyofumi
Shouwa Univ. School Of Med. 2nd Pharanacology
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Uozumi J
Kyushu Univ. Fukuoka Jpn
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Uozumi Jiro
Department Of Urology Faculty Of Medicine Kyushu University
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KOIKAWA Yasuhiro
Department of Urology, Faculty of Medicine, Kyushu University
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UEDA Toyofumi
Department of Urology, Faculty of Medicine, Kyushu University
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Ueda Toyofumi
Department Of Urology Faculty Of Medicine Kyushu University
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Koikawa Yasuhiro
Department Of Urology Faculty Of Medicine Kyushu University
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