Comparative Study of the H_2-Receptor Antagonists Cimetidine, Ranitidine, Famotidine and Nizatidine on the Rabbit Stomach Fundus and Sigmoid Colon

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概要

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• The H_2-receptor antagonists, cimetidine, ranitidine, famotidine and nizatidine, were tested for their effect on the isolated smooth muscle strips from the rabbit stomach fundus and sigmoid colon. These H_2-receptor antagonists were found to possess a concentration-dependent contractile effect on the above smooth muscle preparations and the order of potency was : ranitidine = nizatidine > famotidine > cimetidine. In addition, the smooth muscle preparations from the sigmoid colon were significantly more sensitive to the above compounds than the smooth muscle preparations from the stomach fundus.

• 公益社団法人日本薬学会の論文

著者

• Koutsoviti Papadopoulou

  Department Of Pharmacology Faculty Of Veterinary Medicine Aristotelian University

• Kounenis Georgios

  Department Of Pharmacology Faculty Of Veterinary Medicine Aristotelian University

• Elezoglou Antonia

  Department Of Pharmacology Faculty Of Veterinary Medicine Aristotelian University

• VOUTSAS Anastasios

  Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University

• Voutsas Anastasios

  Department Of Pharmacology Faculty Of Veterinary Medicine Aristotelian University

関連論文

• Inhibition of Acetylcholinesterase by the H_2-Receptor Antagonist Nizatidine
• THE EXCITATORY EFFECT OF THE NEW HISTAMINE H_2-RECEPTOR ANTAGONIST NIZATIDINE (LY 139037) ON THE GUINEA PIG ILEUM
• Comparative Study of the H_2-Receptor Antagonists Cimetidine, Ranitidine, Famotidine and Nizatidine on the Rabbit Stomach Fundus and Sigmoid Colon

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