Suppression of Tumor Cell Growth and Mitogen Response by Aporphine Alkaloids, Dicentrine, Glaucine, Corydine, and Apomorphine
スポンサーリンク
概要
- 論文の詳細を見る
The aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine were shown to have inhibitory activity against mouse tumor cell lines, leukemia P388 and L1210 , melanoma B16,bladder cancer MBC2,and colon cancer Colon 26 in culture. These aporphine alkaloids also inhibited the mitogen-induced lymphocyte proliferation as well as the growth of IL-2 dependent CTLL2 line in a dose-dependent way. Of the four alkaloids apomorphine proved to be most potent in the inhibitory action. Apomorphine treatment resulted in some prolongation of survival time of the mice inoculated i.p. with P388,although its activity was not enough to meet the standard criterion for antitumor activity.
- 公益社団法人日本薬学会の論文
著者
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Nozoe Shigeo
Pharmaceutical Institute, Tohoku University
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NOZOE Shigeo
Faculty of Pharmaceutical Sciences, Tohoku University
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HOJO Hiroshi
Pharmaceutical Institute, Tohoku University
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Endo Takeshi
Fuji Chemical Industry Co. Ltd.
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Nozoe S
Faculty Of Pharmaceutical Sciences Tohoku University
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Nozoe Shigeo
Pharmaceutical Institute Tohoku University
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Imai Yoshihiro
Pharmaceutical Institute Tohoku University
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KONDA Yoshikazu
Pharmaceutical Institute, Tohoku University
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Konda Yoshikazu
Pharmaceutical Institute Tohoku University
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Hojo H
Faculty Of Pharmaceutical Sciences Tohoku University
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Hojo Hiroshi
Pharmaceutical Institute Tohoku University
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