Comparative Pharmacokinetics and Interspecies Scaling of 3'-Azido-3'-deoxy-thymidine (AZT) in Several Mammalian Species

スポンサーリンク

概要

• 論文の詳細を見る

• Interspecies variation in drug disposition can be considered to be a function of species body weight. Therefore, it is possible to establish allometric relationships between pharmacokinetic parameters and species body weight. Interspecies scaling of pharmacokinetic data yielded from laboratory animals can often provide reliable predictions of pharmacokinetic parameters and drug disposition in humans. Significant correlations between 3'-azido-3'-deoxythymidine (AZT) pharmacokinetic parameters (total clearance, renal clearance, nonrenal clearance and steady-state volume of distribution) from mice, rats, dogs, monkeys and humans and body weight were found. Plasma AZT concentration versus chronological time profiles were markedly different for each species. However, when chronological time was converted to pharmacokinetic (physiologic) time these profiles were superimposible. These results demonstrate that interspecies pharmacokinetic scaling can be used to estimate plasma AZT concentrations in humans and can be used to design initial dosage regimens.

• 公益社団法人日本薬学会の論文

著者

• Chu Chung

  Department Of Medicinal Chemistry College Of Pharmacy University Of Georgia

• Schinazi Raymond

  Veterans Affairs Medical Center And Laboratory Of Biochemical Pharmacology Department Of Pediatrics

• BOUDINOT F.

  Department of Pharmaceutics, College of Pharmacy, University of Georgia

• PATEL Bela

  Departments of Pharmaceutics College of Pharmacy, University of Georgia

• GALLO James

  Departments of Pharmaceutics College of Pharmacy, University of Georgia

• CHU Chung

  Medicinal Chemistry and Pharmacognosy College of Pharmacy, University of Georgia

• Gallo James

  Department Of Medical Oncology Fox Chase Cancer Center

• Patel Bela

  Departments Of Pharmaceutics College Of Pharmacy University Of Georgia

• Boudinot F.

  Department Of Pharmaceutics College Of Pharmacy University Of Georgia

• Gallo James

  Departments Of Pharmaceutics College Of Pharmacy University Of Georgia

関連論文

• High-performance liquid chromatographic determination of (-)-β-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection
• Comparative Pharmacokinetics and Interspecies Scaling of 3'-Azido-3'-deoxy-thymidine (AZT) in Several Mammalian Species
• Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis
• Determination of vincristine in mouse plasma and brain tissues by liquid chromatography-electrospray mass spectrometry
• High-performance liquid chromatographic determination of 5-fluorouracil and its prodrugs, tegafur and 4-deoxy-5-fluorouracil, in rat plasma
• High-performance liquid chromatographic method for the determination of AG-331, a novel anti-cancer agent, in human serum and urine using solid-phase extraction and photodiode-array detection
• Determination of carboplatin in plasma and tumor by high-performance liquid chromatography-mass spectrometry
• High-performance liquid chromatographic determination of (-)-β-D-2-aminopurine dioxolane and (-)-β-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-β-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid

スポンサーリンク