Correlation of Contraceptive Activity of Norethisterone and Levonorgestrel Esters with V_<R (w)> Values and Hydrolysis Rates

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概要

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• The relationships between contraceptive activity, hydrophobic character and alkaline hydrolysis rates were studied in three homologous series of norethisterone and levonorgestrel esters. Hydrophobic character was expressed by the high-performance liquid chromatographic retention term, V_<R (w)> or retention volume at 100% aqueous mobile phase. A parabolic and bilinear relationship was shown between log V_<R (w)> and log biological response. No correlation between second-order alkaline hydrolysis rates, K_2,measured in 70% (v/v) aqueous dioxan and contraceptive activity was established.

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著者

• Yeo Soo

  Department Of Pharmacy National University Of Singapore

• Karunanithy Ramasamy

  Department Of Pharmacy National University Of Singapore

• LEUNG Sai

  Department of Pharmacy, National University of Singapore

• Leung Sai

  Department Of Pharmacy National University Of Singapore

関連論文

• Correlation of Contraceptive Activity of Norethisterone and Levonorgestrel Esters with V_ Values and Hydrolysis Rates

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