POSSIBLE MECHANISMS FOR THE ENHANCEMENT OF RECTAL ABSORPTION OF HYDROPHILIC DRUGS AND POLYPEPTIDES BY AQUEOUS POLYACRYLIC ACID GEL
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概要
- 論文の詳細を見る
The mechanisms of absorption enhancing effect by polyacrylic acid gel were investigated in rats. Polyacrylic acid gel significantly enhanced rectal absorption of phenol red, a hydrophilic compound. The enhanced absorption was concentration dependent in the range of 0.01-0.05% w/v polyacrylic acid in gel. The gel also significantly increased the influx and the net influx on water movement in rat rectum. Further, the histological change in rectal epithelium after administration of the polyacrylic acid gel was examined with transmission electron microscopy. The structural changes, which were removal of the mucus and fenestrations of the intercellular spaces 5 and 10 min after administration of polyacrylic acid gel, were observed. These changes were reversible and returned relatively soon to normal levels. Thus, the absorption promoting effect by polyacrylic acid gel may occur mainly with increased water influx as a driving force.
- 公益社団法人日本薬学会の論文
著者
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MORIMOTO Kazuhiro
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Hokkaido Pharmaceutical Uni
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Morimoto Kazuhiro
Department Of Applied Chemistry Faculty Of Engineering Doshisha University
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Morimoto K
Department Of Pharmaceutical Sciences Osaka University Of Pharmaceutical Sciences
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Iwamoto Tsutomu
Department Of Pharmaceutical Sciences Osaka University Of Pharmaceutical Sciences
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MORISAKA KATSUAKI
Department of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences
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Morisaka Katsuaki
Department Of Pharmaceutical Sciences Osaka University Of Pharmaceutical Sciences
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