PEDA : A MICROCOMPUTER PROGRAM FOR PARAMETER ESTIMATION AND DOSAGE ADJUSTMENT IN CLINICAL PRACTICE
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概要
- 論文の詳細を見る
PEDA, an integrated program in BASIC for implementation on microcomputers, has been developed for use in clinical practice to assist dosage adjustment for individual patients. A parameter optimization for individual patients is based on the principle of Bayes' theory and Maximum Likelihood Estimation, and utilizes a prior information on the distribution of population pharmacokinetic parameters, means and variances, as well as serum drug concentrations. The program can accommodate a one-compartment open linear model and a non-linear model at steady state (Michaelis-Menten model) and handle both uniform and non-uniform multiple dosage regimens mostly arising from clinical settings. Clinical examples which demonstrate the ability and the flexibility of the program are provided. The program may also be used as an aid for instruction in clinical pharmacokinetics.
- 公益社団法人日本薬学会の論文
著者
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HIGUCHI Shun
Department of Clinical Pharmacokinetics, Graduate School, Kyushu University
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AOYAMA Toshinobu
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Aoyama Toshinobu
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Higuchi S
Department Of Clinical Pharmacokinetics Graduate School Of Pharmaceutical Sciences Kyushu University
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Higuchi S
Kyushu Univ. Fukuoka Jpn
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Higuchi Shun
Department Of Clinical Pharmacokinetics Division Of Pharmaceutical Sciences Kyushu University
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Higuchi Shun
Department Of Clinical Pharmacokinetics Graduate School Of Pharmaceutical Sciences Kyushu University
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HORIOKA Masayoshi
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Aoyama T
Kyushu Univ. Fukuoka Jpn
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Horioka Masayoshi
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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