AUGMENTATION OF HOST'S IMMUNITY BY COMBINED CRYODESTRUCTION OF SARCOMA 180 AND ADMINISTRATION OF PROTEIN-BOUND POLYSACCHARIDE, EA_6,ISOLATED FROM FLAMMULINA VELUTIPES (CURT.ex FR.) SING.IN ICR MICE

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Augmentation of the host's immunity by combined in situ freeze-destruction of the tumor (cryosurgery) and administration of the antitumor active protein-bound polysaccharide, EA_6,isolated from a hot water extract of an edible mushroom, Flammulina velutipes (CURT.ex FR.) SING., was investigated in sarcoma 180 bearing ICR mice. Oral administration (p.o.)of the EA_6 stimulated anti-sheep red blood cells (SRBC) IgM antibody-producing activity of the spleen cells, and also delayed hypersensitivity (DTH) against SRBC in swelling of the foot pads of the tumor-bearing hosts. When EA_6 p.o. was combined with cryosurgery, further augmentation of IgM-producing activity and DTH reaction to SRBC was recognized as compared with the EA_6 single use. But the reticuloendothelial system of the mice, estimated by carbon clearance test, was not activated by EA_6 p.o. or combined with cryosurgery.