POLYSACCHARIDES IN FUNGI. XIV. ANTI-INFLAMMATORY EFFECT OF THE POLYSACCHARIDES FROM THE FRUIT BODIES OF SEVERAL FUNGI
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概要
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Anti-inflammatory assays on the carrageenin-induced edema and scald-induced hyperalgesia in the hindpaw of rats were studied on polysaccharides obtained from the fruit bodies of various fungi (polysaccharide AC, BC : Tremella fuciformis ; MEA, MHA, MCW-A, MCW-N : Auricularia auricula-judae ; T-2-HN : Dictyophora indusiata ; G-A : Ganoderma japonicum). The purified polysaccharides MHA, MCW-A, G-A and T-2-HN exhibited a significant inhibitory effect on carrageenin edema. Among these polysaccharides, T-2-HN (partially O-acetylated α-D-mannan) also showed the marked inhibitory effect on scald hyperalgesia. We have found that T-2-HN has more potent anti-inflammatory activity than phenylbutazone in the above two inflammatory models. Since the purified polysaccharide is free from protein and lipid, it is clear that anti-inflammatory effect arises from the polysaccharide itself. The polysaccharides (T-2-HN, locust bean gun, xanthan gum) had little effect on the metabolism of arachidonic acid in canine platelets. The mechanism of the anti-inflammatory activity of the polysaccharide remains obscure.
- 公益社団法人日本薬学会の論文
著者
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HARA CHIHIRO
Gifu College of Pharmacy
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TANAKA YUSHIRO
Department of Pharmacology, Nippon Roche Research Center
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Tanaka Yushiro
Department Of Pharmacology Nippon Roche Research Center