EFFECTS OF DILAZEP ON FIBRINOLYTIC SYSTEM IN ANIMALS. II. ENHANCING EFFECT OF DILAZEP ON PLASMINOGEN ACTIVATOR RELEASE IN THE ISOLATED PERFUSED PIG EAR

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The influence of drugs on the release of plasminogen activator was studied in the isolated perfused pig ear. The pig ear was perfused with oxygenated Tyrode's solution pH 7.4,at 37℃ via main artery and perfusate from the veins was collected at 2 min intervals. The drug was injected into a rubber tube connected in the front of arteria cannula, and the fibrinolytic activity of perfusate collected was measured by the fibrin plate method using plasminogen-containing bovine fibrinogen. Under the test condition, dilazep enhanced plasminogen activator release (PA release) in a dose-dependent fashion ranging 10 to 100 μg, however, it did not affect the perfusion pressure. Hypotensors, namely acetylcholine (0.1-3μg), bradykinin (0.1-3μg) and histamine (0.1-3μg) enhanced also the PA release in a dose-dependent fashion with no effects on perfusion pressure. Vasoconstricting drugs, namely phenylephrine (0.3-10 μg), norepinephrine (0.1-3 μg) and serotonin (0.1-3μg) exerted hypertensive effects on perfusion pressure in a dose-dependent fashion, however, it did not cause the PA release.
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