ASSIGNMENT OF CIRCULAR DICHROISM SPECTRA OF 2-(4'-HYDROXYPHENYLAZO) BENZOIC ACID INDUCED BY BOVINE SERUM ALBUMIN TO THE AZO FORM

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概要

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• In the displacement study, the effects of tolbutamide on the absorption spectra and induced CD spectra of 2-(4'-hydroxyphenylazo) benzoic acid (HABA)-bovine serum albumin (BSA) complex were investigated using the samples obtained from equilibrium dialysis at pH 7.40. The binding of tolbutamide to BSA enhanced the binding of the azo form in spite of the displacement of the hydrazone form of bound HABA at the molar ratio of HABA to BSA of 0.65,causing the increase in the negative ellipticity at 445 nm, which was termed the C band. The C band could be assinged to the azo form of bound HABA.

• 公益社団法人日本薬学会の論文

著者

• Tsuchiya Seishi

  Tokyo College Of Pharmacy

• SAKURAI TAMIKO

  Tokyo College of Pharmacy

• MATSUMARU HIDEO

  Tokyo College of Pharmacy

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• ASSIGNMENT OF CIRCULAR DICHROISM SPECTRA OF 2-(4'-HYDROXYPHENYLAZO) BENZOIC ACID INDUCED BY BOVINE SERUM ALBUMIN TO THE AZO FORM
• EFFECTS OF PHENYLBUTAZONE AND MEFENAMIC ACID ON TWO CLASSES OF BINDING SITES OF 2-(4'-HYDROXYPHENYLAZO) BENZOIC ACID ON BOVINE SERUM ALBUMIN CHARACTERIZED BY ABSORPTION SPECTRA AND CIRCULAR DICHROISM SPECTRA
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