MODIFLED DISTRIBUTION OF METHYLMERCURY BY ADDITIONAL EXPOSURE TO ELEMENTAL MERCURY OR MERCURIC CHLORIDE IN MICE FED METHYLMERCURIC CHLORIDE
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概要
- 論文の詳細を見る
Male IVCS mice fed pellets containing 8 nmol methylmercuric chloride (MMC)/g feed for 32 days were additionally inhaled elemental mercury vapor (Hg゜) or injected mercuric chloride (Hg^<2+>). The modified distribution of accumulated organic mercury was observed 24 hr after exposure to inorganic mercurials. The body burden of organic mercury decreased significantly in MMC+Hg^<2+> treated mice and moderately (not significant) in MMC+Hg゜treated mice when compared with MMC treated mice. In spite of the decreased body burden, the organic mercury levels in brain, kidneys and blood of MMC+Hg゜ treated mice, and in kidneys of MMC+Hg^<2+> treated mice were elevated. In bile, organic mercury concentration after Hg゜ or Hg^<2+> exposure was reduced. The decrease of the blood cells-to-plasma ratio of organic mercury in mice after Hg゜ exposure is in agreement with the data reported for workers exposed to mercury vapor.
- 公益社団法人日本薬学会の論文
著者
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NOBUNAGA TOSHIMA
Institute of Animal Experiments, School of Medicine, Tohoku University
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Nobunaga Toshima
Institute Of Animal Experiments School Of Medicine Tohoku University
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Nobunaga Toshima
Department Of Laboratory Animal Science Nippon Veterinary And Animal Science University
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YAMAMOTO REIKO
Institute of Experimental Animals, School of Medicine, Tohoku University
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SATOH HIROSHI
Institute of Experimental Animals, School of Medicine, Tohoku University
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SUZUKI TSUGUYOSHI
Institute of Experimental Animals, School of Medicine, Tohoku University
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Satoh Hiroshi
Department Of Public Health School Of Medicine Tohoku University
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Suzuki Tsuguyoshi
Institute Of Experimental Animals School Of Medicine Tohoku University
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Yamamoto Reiko
Institute Of Experimental Animals School Of Medicine Tohoku University
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