MUTAGENICITY OF N-ACYLGLYCINOHYDROXAMIC ACIDS AND RELATED COMPOUNDS

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The mutagenic activity of twenty-nine new N-acylglycinohydroxamic acids and related compounds was tested on Bacillus subtilis (Rec^+, Rec^-) and Salmonella typhimurium (TA 98,TA 100). All the N-(substituted-benzoyl) glycinohydroxamic acids, except 3-acetylaminobenzoyl-derivative, were shown to be mutagenic to both test bacteria, whereas most of the N-aliphatic acylglycinohydroxamic acids were found to be non-mutagenic. In the present study, we discussed our observations focussing on the structure-activity correlation between their chemical structures and mutagenic activities.
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