ACTIVATION OF AUTONOMIC NERVOUS SYSTEM DURING EXPOSURE OF RATS TO RESTRAINT AND WATER IMMERSION STRESS. I. ACTIVATING PATTERN OF AUTONOMIC NERVOUS SYSTEM
スポンサーリンク
概要
- 論文の詳細を見る
We studied the activity of one division of the autonomic nervous system, independently of the other, under restraint and water (25°) immersion. For such evaluation, heart rate, gastric motility and catecholamine content of tissues or urine were measured in rats of which the autonomic nervous activity was reduced by adrenal medullectomy (AMX), guanethidine (GNT), atropine (ATR), or their combinations. Heart rate in the controls was increased after restraint or immediately after water immersion and this change was blocked by AMX plus GNT. ATR accelerated the heart rate, but did not affect the extent of the stress-induced increase in the heart rate. With an increase in the duration of water immersion, a decrease in heart rate occurred closely linked with hypothermia in all animal groups, suggesting that heart rate was influenced by hypothermia more prominently than by the autonomic nervous controls. AMX plus GNT significantly shortened the occurrence time of increased gastric motility which was observed after water immersion, while ATR completely inhibited an increase in gastric motility. The determination of catecholamine content showed a stress-induced activation of sympatho-adrenal function and its blockade by the treatment with AMX plus GNT. It is finally suggested that the stress procedures used here may immediately enhance the sympatho-adrenal activity lasting for at least 3 hr and steadily raise the vagal activity reaching the plateau 2 hr later.
- 公益社団法人日本薬学会の論文
著者
-
Harada Masatoshi
Faculty Of Pharmaceutical Sciences Chiba University
-
Yano Shingo
Faculty Of Pharmaceutical Sciences Chiba University
-
SUGIHARA MASARU
Faculty of Pharmaceutical Sciences, University of Chiba
-
Sugihara Masaru
Faculty Of Pharmaceutical Sciences University Of Chiba
関連論文
- PHARMACOLOGICAL EVALUATION OF ALPHA-1 AND ALPHA-2 ADRENOCEPTOR BLOCKING ACTIVITIES AND Ca^ ENTRY BLOCKING ACTIVITY OF ALKALOIDS CONTAINED IN UNCARIA HOOKS AND THEIR RELATED DERIVATIVES
- PERIPHERAL AND CENTRAL EFFECTS OF ATROPINE AND CHLORPROMAZINE ON GASTRIC MOTILITY AND ULCERATION IN STRESSED RATS
- PHARMACOLOGICAL STUDIES ON CHINESE CINNAMON. V. CATECHOLAMINE RELEASING EFFECT OF CINNAMALDEHYDE IN DOGS
- PHARMACOLOGICAL STUDIES OF GARDENIA FRUIT. III. RELATIONSHIP BETWEEN IN VIVO HYDROLYSIS OF GENIPOSIDE AND ITS CHOLERETIC EFFECT IN RATS
- PHARMACOLOGICAL STUDIES OF GARDENIA FRUIT. V. MECHANISMS OF INHIBITORY EFFECT OF GENIPIN ON GASTRIC ACID SECRETION AND ITS FACILITATORY EFFECT ON BILE SECRETION IN RATS
- EFFECT OF JAPANESE ANGELICA ROOT AND PEONY ROOT ON UTERINE CONTRACTION IN THE RABBIT IN SITU
- GASTRIC MUCOSAL SUSCEPTIBILITY TO EROSIVE ACTION OF ACID IN STRESSED RATS AND ITS MODIFICATION BY VARIOUS TREATMENTS
- CONTRIBUTION OF ALKALOID FRACTION TO PRESSOR AND HYPERGLYCEMIC EFFECT OF CRUDE EPHEDRA EXTRACT IN DOGS
- ACTIVATION OF AUTONOMIC NERVOUS SYSTEM DURING EXPOSURE OF RATS TO RESTRAINT AND WATER IMMERSION STRESS. I. ACTIVATING PATTERN OF AUTONOMIC NERVOUS SYSTEM
- ACTIVATION OF AUTONOMIC NERVOUS SYSTEM DURING EXPOSURE OF RATS TO RESTRAINT AND WATER IMMERSION STRESS. II. COMPARISON WITH RESTRAINT STRESS
- CHEMICAL AND PHARMACOLOGICAL STUDIES ON THE CONSTITUENTS OF ZEDOARY CULTIVATED IN YAKUSHIMA JAPAN
- Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.