Synthesis and Evaluation of Some Hydroxyproline-Derived Peptidomimetics as Isoprenyltransferase Inhibitors

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概要

• 論文の詳細を見る

• CA_1A_2X peptidomimetics containing a modified proline at position A_2 were prepared and evaluated for their ability to inhibit farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) in enzymatic and cellbased assays. These compounds inhibited farnesylation of H-ras in vitro in the high nanomolar to low micromolar IC_<50> range.

• 公益社団法人日本薬学会の論文
• 2000-05-01

著者

• Lewis Michael

  Eisai Research Institute 4 Corporate Drive

• Ackermann Karen

  Eisai Research Institute 4 Corporate Drive

• Rowell Ceryl

  Eisai Research Institute 4 Corporate Drive

• GARCIA Ana

  Eisai Research Institute, 4 Corporate Drive

• KOWALCZYK James

  Eisai Research Institute, 4 Corporate Drive

• Garcia Ana

  Eisai Research Institute 4 Corporate Drive

• Kowalczyk James

  Eisai Research Institute 4 Corporate Drive

• O'connell Celeste

  Eisai Research Institute 4 Corporate Drive

• Rowell Cheryl

  Eisai Research Institute, 4 Corporate Drive

関連論文

• Synthesis and Evaluation of Some Hydroxyproline-Derived Peptidomimetics as Isoprenyltransferase Inhibitors

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