Stereselective Reactions. XXXII. Enantioselective Deprotonation of 4-tert-Butylcyclohexanone by Fluorine-Containing Chiral Lithium Amides Derived from 1-Phenylethylamine and 1-(1-Naphthyl)ethylamine

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概要

• 論文の詳細を見る

• Enantioselective deprotonation of 4-tert-butylcyclohexanone was examined using 1-phenylethylamine- and 1-(1-naphtyl)ethylamite-derived chiral lithium amides having an alkyl or a fluoroalkyl substituent at the amide nitrogen. The lithium amides having a 2,2,2-trifluoroethyl group on the amide nitrogen are easily accessible in both enantiomeric forms, and were found to induce good enantioselectivity in the present reaction.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• Koga Kenji

  (present Address)research And Education Center For Materials Science Nara Institute Of Science And T

• Aoki Kazumasa

  (present Address)medicinal Chemistry Research Lab. Sankyo Co. Ltd. :graduate School Of Pharmaceutica

関連論文

• Stereselective Reactions. XXXII. Enantioselective Deprotonation of 4-tert-Butylcyclohexanone by Fluorine-Containing Chiral Lithium Amides Derived from 1-Phenylethylamine and 1-(1-Naphthyl)ethylamine

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