Butyrolactones from Aspergillus terreus

概要

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In the process development of lovastatin using Aspergillus terreus DRCC 152 in solid state fermentation, we have isolated a new butyrolactone-IV (3) along with the previously reported butyrolactone-I (1) and butyrolactone-II (2) produced under submerged conditions. The structure of compound 3 has been characterized as 3-hydroxy-5-{2-(1-hydroxy-1-methylethyl)-2-(R)-2,3-dihydro-benzo[b]furan-5 ylmethyl}-4-(4-hydroxyphenyl)-5-methoxycarbonyl-(5R)-2,5-dihydro-(5R)-2,5-dihydro-2-furanone on the basis of spectroscopic studies. The absolute stereochemistry has been determined by single crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of these compounds were determined.
公益社団法人日本薬学会の論文
2000-04-01