Effect of the Linking Position of a Side Chain in Bis(quinolylmethyl)ethylenediamine as a DNA Binding Agent
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概要
- 論文の詳細を見る
Two bisquinoline derivatives, N, N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N, N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay. These compounds exhibited apparent AT-specificity suggesting minor groove binding in addition to intercalation.
- 公益社団法人日本薬学会の論文
- 2000-04-01
著者
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MIKATA Yuji
Department of Chemistry, Faculty of Science, Nara Women's University
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YANO Shigenobu
Department of Chemistry, Faculty of Science, Nara Women's University
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Mikata Y
Kyosei Science Center Nara Women's University
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Mikata Yuji
Department Of Chemistry Faculty Of Science Nara Women's University
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Yano Shigenobu
Department Of Chemistry Faculty Of Science Nara Women's University
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ONCHI Yoko
Department of Chemistry, Faculty of Science, Nara Women's University
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KISHIGAMI Maki
Department of Chemistry, Faculty of Science, Nara Women's University
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Kishigami Maki
Department Of Chemistry Faculty Of Science Nara Women's University
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Onchi Yoko
Department Of Chemistry Faculty Of Science Nara Women's University
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