Facile Synthesis of Opitcally Active γ-Lactones via Lipase-catalyzed Reaction of 4-Substituted 4-Hydroxybutyramides

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概要

• 論文の詳細を見る

• Lipase-catalyzed transesterification of acemic 4-substituted 4-hydroxybutyramides with succinic anhydride proceeded enantioselectively to afoord (S)-succinic acid monoester and unreacted (R)-4-hydroxybutyramide derivative, which were separated easily by treatment with an alkaline solution. Both enantiomers were convereted easily to opitcally active γ-substituted γ-butyrolactones.

• 公益社団法人日本薬学会の論文
• 2000-02-01

著者

• Terao Yoshiyasu

  Graduate School Of Nutritional & Environmental Sciences University Of Shizuoka

• Fukawa Hidemichi

  Research Center Toyotama Koryo Co. Ltd.

• MATSUMURA Yassufumi

  Research Center, Toyotama Koryo Co., Ltd.

• ENDO Teruko

  Research Center, Toyotama Koryo Co., Ltd.

• CHIBA Mituo

  Research Center, Toyotama Koryo Co., Ltd.

• Chiba M

  Research Center Toyotama Koryo Co. Ltd.

• Matsumura Yassufumi

  Research Center Toyotama Koryo Co. Ltd.

• Endo Teruko

  Research Center Toyotama Koryo Co. Ltd.

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• Formation of Pyrido[3,2-f]quinoxalines by Reaction of 6-Amino-2,3-dimethylquinoxaline with Aldehydes
• Synthesis of (R)-(-)-Muscone via Enzymatic Resolution of 3-Methylcyclopentadecan-1-ol
• LIPASE-CATALYZED OPTICAL RESOLUTION OF 2-OXAZOLIDINONES
• Facile Synthesis of Opitcally Active γ-Lactones via Lipase-catalyzed Reaction of 4-Substituted 4-Hydroxybutyramides

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