Synthesis and Cytotoxic Activity of a Series of Diacetylenic Compounds Related to Falcarindiol

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概要

• 論文の詳細を見る

• The synthesis of a series of diacetylenic compounds related to the natural product falcarindiol has been carried out. Unsymmetrical diacetylenes were prepared by a modification of the Cadiot-Chodkiewicz coupling reaction, while a Glaser coupling was used to prepare symmetrical diacetylenes. These compounds have been tested for in vitro cytotoxic activity aginst Hep-G2,and H-4-II-E cell lines. Diacetylenes with additional unsaturation at C-1,2,appended with hydroxyl groups at C-3 and C-8,or with long hydrophobic chains, exhibited IC_<50> values in the micromolar range.

• 公益社団法人日本薬学会の論文
• 2000-11-01

著者

• SETZER Mary

  Department of Chemistry, University of Alabama in Huntsville

• Setzer Mary

  Departments Of Chemistry And Biological Sciences University Of Alabama In Huntsville Huntsville

• Setzer William

  Departments Of Chemistry And Biological Sciences University Of Alabama In Huntsville Huntsville

• Setzer William

  Department Of Chemistry University Of Alabama In Huntsville

• Wells Eric

  Departments Of Chemistry And Biological Sciences University Of Alabama In Huntsville Huntsville

• Moriarity Debra

  Departments Of Chemistry And Biological Sciences University Of Alabama In Huntsville Huntsville

• Moriarity Debra

  Department Of Biological Sciences University Of Alabama In Huntsville

• GU Xuyuan

  Departments of Chemistry and Biological Sciences, University of Alabama in Huntsville, Huntsville

• Gu Xuyuan

  Departments Of Chemistry And Biological Sciences University Of Alabama In Huntsville Huntsville

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• Identification of the main volatile compounds in the leaf and flower of Tithonia diversifolia (Hemsl) Gray
• Synthesis and Cytotoxic Activity of a Series of Diacetylenic Compounds Related to Falcarindiol

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