Total Synthesis of Polyamine Toxin HO-416b and Agel-489 Using a 2-Nitrobenzenesulfonamide Strategy
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概要
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Total synthesis of spider toxins HO-416b (1) and Agel-489 (2) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. In this strategy, the C-N bonds were constructed by alkylation of sulfonamides with alkyl halides or Mitsunobu reaction with the corresponding alcohol.Beginning with monoprotection of the symmetrical diamine, the construction of the backbone from diamine 3 was efficiently accomplished in 7 steps for 14 and 9 steps for 29. Removal of the Ns group while the substrate was attached to a novel solid support enabled the efficient isolation of this highly polar compound.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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Kan Toshiyuki
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Kan Toshiyuki
Graduate School Of Pharmaceutical Sciences University Of Tokyo Crest The Japan Science And Technolog
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Fukuyama T
Graduate School Of Pharmaceutical Sciences University Of Tokyo Crest The Japan Science And Technolog
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Fukuyama Tohru
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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HIDAI Yuko
Graduate School of Pharmaceutical Sciences, University of Tokyo CREST, The Japan Science and Technol
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Hidai Yuko
Graduate School Of Pharmaceutical Sciences University Of Tokyo Crest The Japan Science And Technolog
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