Syntheses of Chlorpromazine Undecahydrododecaborate and Nonahydro-decaborate-Promising Agents for Neutron Capture Therapy of Malignant Melanoma
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概要
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It has been suggested by dermatologists that boron compounds of chlorpromazine are promising agents for neutron capture therapy of malignant melanoma. The compounds are desired to have a high boron content, good stability, and sufficient solubility in water. To fulfil these requirements, chlorpromazine undecahydrododecaborate and nonahydrodecaborate have been synthesized starting from 2-chloro-10 (3-bromopropyl) phenothiazine and ammonioundecahydrododecaborate or 2-ammoniononahydrodecaborate, respectively.
- 公益社団法人日本薬学会の論文
- 1976-04-25
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