Interaction d'un Corps Cancerogene le Methyl-7 benzo [α] anthracene avec de 1'ADN en Presence de Microsomes Extraits du Foie de Hamsters

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概要

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• The metabolites of 7-methylbenzo [α] anthracene (MBA) by NADPH requiring microsomal system from livers of phenobarbital-treated hamsters were analyzed by using ^3H-MBA. Then, these systems were applied to the reactions of MBA with the calf thymus DNA. The binding ratio of ^3H-MBA to DNA was estimated at 8 mμg of MBA/mg DNA, that is, 1 mole of MBA/100000 nucleotides. The fluorescence spectra indicate an analogy of delocalized electronic system to the parent hydrocarbon, but an evident difference from the DNA-MBA epoxide in the K-region. The formation, observed on the spectra, of MBA-DNA complex by microsomal system was similar to that of MBA-DNA complex by cell cultures.

• 公益社団法人日本薬学会の論文
• 1976-02-25

著者

• 川村 熙子

  Section De Physique Et Chimie De La Fondation Curie Institut Du Radium

関連論文

• Interaction d'un Corps Cancerogene le Methyl-7 benzo [α] anthracene avec de 1'ADN en Presence de Microsomes Extraits du Foie de Hamsters

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