A Comparative Study on Phosphate Protecting Groups in Oligonucleotide Synthesis by the Phosphotriester Approach

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概要

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• The efficiencies of various of phosphate protecting groups in the synthesis of internucleotidic bonds by the phosphotriester approach have been studied. We found that in the coupling reaction using alkyl groups as phosphate protecting groups of internucleotidic bonds, extensive sulfonation of the 5'-hydroxyl group of nucleoside occurred, whereas when aryl groups were used in place of alkyl groups, the sulfonation did not occur.

• 公益社団法人日本薬学会の論文
• 1982-08-25

著者

• 河野 勤

  Laboratory Of Organic Chemistry Chiba Institute Of Technology

• 高久 洋

  Laboratory of Bioorganic Chemistry, Department of Industrial Chemistry, Chiba Institute of Technolog

• 高久 洋

  Laboratory Of Bioorganic Chemistry Chiba Institute Of Technology

関連論文

• Synthesis and Properties of 2', 5'-Adenylate Trimers Bearing 2'-Terminal 8-Bromo- or 8-Hydroxyadenosine
• 3,4-DIMETHOXYBENZYL GROUP : A NEW PROTECTING GROUP FOR THE GUANOSINE RESIDUE DURING OLIGONUCLEOTIDE SYNTHESIS
• USE OF THE(BUTYLTHIO)CARBONYL GROUP TO PROTECT URACIL AND GUANINE RESIDUES IN OLIGORIBONUCLEOTIDE SYNTHESIS(Communications to the Editor)
• A CONVENIENT METHOD FOR THE PREPARATION OF CARBOXYLIC ESTERS
• A Comparative Study on Phosphate Protecting Groups in Oligonucleotide Synthesis by the Phosphotriester Approach
• SOLID-PHASE SYNTHESIS OF DEOXYRIBOOLIGONUCLEOTIDES BY THE PHOSPHOTRIESTER METHOD EMPLOYING A NEW POLYMER SUPPORT
• CATALYTIC EFFECT OF CESIUM FLUORIDE FOR ALKYLATION OF PHOSPHORIC ACIDS
• AN EFFICIENT PHOSPHORYLATING AGENT FOR THE SYNTHESIS OF NUCLEOSIDE 3'-PHOSPHODIESTER INTERMEDIATES IN OLIGONUCLEOTIDE SYNTHESIS
• Studies of Phosphorylation. III. Effect of Metallic Compound on the Phosphorylation of Alcohols, Phosphates, and Nucleosides by 8-Quinolyl Phosphates
• A Convenient Method for the Preparation of Mixed Diesters of Phosphoric Acid and Pyrophosphates
• Studies of Phosphorylation. V. 8-Quinolyl Dihydrogen Phosphate as a Phosphorylating Reagent in Nucleotide Synthesis

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