N-Substituted Phenanthroimidazolamines from the Reaction of Phenanthrenequinone with Monosubstituted Guanidines
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概要
- 論文の詳細を見る
The reaction of 9,10-phenanthrenequinone (PTQ) with cyclohexylguanidine or isopropylguanidine in alkaline aqueous ethanol yielded 1H-phenanthro [9,10-d] imidazol-2-amine (PIA) as the major product and N-cyclohexyl-PIA or N-isopropyl-PIA, respectively, as a minor product. The same reaction with phenylguanidine or tert-butylguanidine yielded only the corresponding N-substituted PIAs. The yield of N-isopropyl-PIA was increased seven-fold when NaBH_4 was added to the reaction mixture of PTQ and isopropylguanidine. N-Substituted PIAs are fluorescent and can be separated from PIA by thin layer chromatography.
- 社団法人日本薬学会の論文
- 1982-11-25
著者
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斎藤 節生
Faculty of Pharmaceutical Sciences, Josai University
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斎藤 節生
Faculty Of Pharmaceutical Sciences Josai University
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斎藤 節生
Department of Pathology, D-006, University of California
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尾崎 宏
Department of Pathology, D-006, University of California
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尾崎 宏
Department Of Pathology D-006 University Of California:(present Address)insiitute For Protein Resear
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