Determination of Stability Constants of Complexes by the Nonlinear Optimization Method and Analysis of Solubility Curves

概要

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Solubilization of the slightly soluble drug 3-benzimidoyl-2-hydroxy-1,4-naphthoquinone was studied by the solubility method using sodium benzoate and several phenol derivatives as solubilizing agents. Their solubilizing mechanism is believed to involve the formation of soluble complexes between drugs and solubilizing agents. Solubility curves observed in cases where complexes of high order were formed at the same time were analyzed by using the nonlinear optimization technique, i.e., the Gauss-Newton method and the conjugate gradient method. Further study is needed to check the accuracy of the estimated parameters.
社団法人日本薬学会の論文
1982-01-25