Intramolecular Cyclization of Alkylhydroxylamines in Acids

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概要

• 論文の詳細を見る

• Alkylhydroxylamines having a benzene ring in the molecule were subjected to intramolecular cyclization in trifluoroacetic acid or in the presence of Lewis acids, and benzenefused six-membered heterocycles were obtained in moderate yields from the cyclization reaction of O-acylhydroxylamines. The effect of a methoxyl group on the benzene ring was also investigated. The m-methoxy compound (1j) cyclized to give 6-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline (2e), while the p-methoxy compound (1k or 1l) cyclized to give the same product (2e). These unusual results could be explained in terms of a spiro-intermediate (3a).

• 公益社団法人日本薬学会の論文
• 1981-06-25

著者

• 河瀬 雅美

  Faculty of Pharmaceutical Science,Josai University

• 菊川 靖雄

  Faculty of Pharmaceutical Sciences, Josai University

• 河瀬 雅美

  城西大・薬

• 菊川 靖雄

  Faculty Of Pharmaceutical Sciences Josai University

• 菊川 靖雄

  城西大学

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