Syntheses of Erythrinan Alkaloids : (±)-Coccolinine, (±)-Isococculidine, (±)-Coccuvinine, and (±)-Cocculidine
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概要
- 論文の詳細を見る
Total syntheses of 'abnormal-type' erythrinan alkaloids, (±)-coccolinine (1), (±)-isococculidine (2), (±)-coccuvinine (3) and (±)-cocculidine (4), are described. Mondon's glyoxylic ester synthesis was successfully applied in these syntheses. The key intermediate, 16-ethoxycarbamido-2,15-dimethoxyerythrinan-7,8-dione (7), was obtained by condensation of 3-ethoxycarbamido-4-methoxyphenylethylamine (5) with ethyl 4-methoxycyclohexanone-2-glyoxylate (6), followed by treatment with phosphoric acid. The ethoxycarbamido group at the C_<16> position was effectively employed as a regiospecific para-directing group in the isoquinoline ring closure.
- 公益社団法人日本薬学会の論文
- 1981-02-25
著者
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十一 元晴
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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安東 良子
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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十一 元晴
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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安東 良子
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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藤谷 ゆかり
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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藤谷 ゆかり
武庫川女子大学薬学部
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