Deoxygenation of Amino-Glycoside Antibiotics via Anhydro Intermediates. III. New Synthesis of 3'-Deoxykanamycin A

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概要

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• A new synthetic route has been exploited for the large-scale production of 3'-deoxykanamycin A. The key stage in the synthesis involves the formation of the 3', 4'-anhydro-3'-epi derivative (9) or 2', 3'-anhydro-3'-epi derivative (10) followed by conversion to the 3'-deoxy derivative by reduction with Raney-nickel or sodium borohydride. Compound (9) or (10) was prepared by the treatment of 2', 2"-di-O-benzoyl-3'-O-methylsulfonyl-tetra-N-ethoxycarbonylkanamycin A with sodium methoxide.

• 公益社団法人日本薬学会の論文
• 1981-12-25

著者

• 深津 俊三

  Central Research Laboratories Meiji Seika Kaisha Ltd.

• 米田 利夫

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• 松野 富雄

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• 七星 日出隆

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• 米田 利夫

  Central Research Laboratories Meiji Seika Kaisha Ltd.

• 七星 日出隆

  Central Research Laboratories Meiji Seika Kaisha Ltd.

関連論文

• Deoxygenation of Amino-Glycoside Antibiotics via Anhydro Intermediates. III. New Synthesis of 3'-Deoxykanamycin A
• Deoxygenation of Amino-Glycoside Antibiotics via Anhydro Intermediates. II. Improved Syntheses of 3', 4'-Dideoxykanamycin A and 4'-Deoxykanamycin A

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