Synthesis of 5-Membered Heterocycles and Related Compounds

概要

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Some 1-(2,4-dichlorophenoxy and 2,4,5-trichlorophenoxy) acetyl-4-arylthiosemicarbazides were prepared from corresponding chlorophenoxyacetohydrazide. The resulting thiosemicarbazides were cyclised into 1,3,4-thiadiazoles and 5-mercapto-1,2,4-triazoles under different reaction conditions. The mercapto compounds were converted into sulphides and sulphones. N'-arylidene (2,4-dichlorophenoxy) acetohydrazides and 5-substituted-1,3,4-oxadiazole-2-thiones were also prepared from (2,4-dichlorophenoxy and 2,4,5-trichlorophenoxy) acetohydrazides separately and were subjected to Mannich reaction. Some of these compounds were evaluated as fungicides against Aspergillus niger.
公益社団法人日本薬学会の論文
1974-12-25