The Improved Syntheses of dl-Ibotenic Acid and Muscimol

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概要

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• dl-Ibotenic acid (I) was synthesized in a better yield than the known methods, starting from diethyl 3-chloroglutaconate (VII). Reaction of VII with hydroxylamine in the presence of sodium hydroxide followed by esterification afforded ethyl 3-hydroxy-5-isoxazoleacetate (IV), which was, after benzenesulfonylation, brominated with NBS to ethyl α-bromo-3-benzenesulfonyloxy-5-isoxazoleacetate (X). Hydrolysis and treatment with ammonia of X gave I. Synthesis of muscimol (II) from IV was also described.

• 社団法人日本薬学会の論文
• 1971-01-25

著者

• 中村 紀雄

  New Lead Research Laboratories:sankyo Co. Ltd.

• 中村 紀雄

  Central Research Laboratories, Sankyo Co., Ltd.

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• The Improved Syntheses of dl-Ibotenic Acid and Muscimol
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• Studies on Acetylenic Compounds. XLIII. Synthesis of Ibotenic Acid
• Studies on Acetylenic Compounds. XXXIX. The Addition Reaction of Cyanogen Bromide to Acetylenic Compounds

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