Hydrodynamic and Diffusional Considerations in Assessing the Effects of Surface Active Agents on the Dissolution Rate of Drugs

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概要

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• The influence of a non-ionic surface active agent on the dissolution rate of benzoic and salicylic acids has been investigated and dissolution mechanisms have been examined as a function of the hydrodynamics of the system. Clearly, the dissolution rate of a solid in a micellar solution is not proportional to the solubility of the compound in the dissolution medium. Evaluation of dissolution rate data and theories has led to the conclusion that, depending upon hydrodynamic conditions, the dissolution rate of a solid will be proportional to the effective diffusion coefficient raised to a power between 0.5 and 1.0.

• 公益社団法人日本薬学会の論文
• 1970-04-25

著者

• Gibaldi Milo

  Department Of Pharmaceutics School Of Pharmacy State University Of New York At Buffalo

• Weiner Norman

  Department Of Pharmaceutics College Of Pharmacy University Of Michigan

• Weiner Norman

  Department Of Pharmaceutics School Of Pharmacy State University Of New York At Buffalo

• Feldman Stuart

  Department Of Pharmaceutics School Of Pharmacy State University Of New York At Buffalo

関連論文

• An Explanation of the Minima in Surface Tension-Log Concentration Profiles
• Hydrodynamic and Diffusional Considerations in Assessing the Effects of Surface Active Agents on the Dissolution Rate of Drugs

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