Evaluation for Intrinsic Skin Permeation of Unstable Compounds

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概要

• 論文の詳細を見る

• An evaluation method is proposed for the intrinsic skin permeation rate of unstable compounds. Vitamin C and vitamin E were used as the model compounds. The degradation of vitamin C and E in the solutions followed first-order kinetics with degradation constants of 0.26h^<-1> and 0.014h^<-1>, respectively. The apparent skin permeation profiles of vitamin C and E in vitro, approximated by a nonlinear profile of the polynomial regression method, was corrected for intrinsic permeation rate considering first-order degradation in the receptor solution. The intrinsic profiles evaluated agreed well with the ones determined from radio-labelled compounds, indicating the feasibility of the present analysis.

• 公益社団法人日本薬学会の論文
• 1996-08-15

著者

• Lee Ae-ri

  Controlled Drug Delivery Research Center College Of Pharmacy Rutgers University:(present Address)col

• Tojo Kakuji

  Controlled Drug Delivery Research Center College Of Pharmacy Rutgers University:(present Address)dep

関連論文

• Characterization of Skin Permeation of Vitamin C : Theoretical Analysis of Penetration Profiles and Differential Scanning Calorimetry Study
• Evaluation for Intrinsic Skin Permeation of Unstable Compounds
• Skin permeation of drugs - Diffusion and partitioning.

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