Experimental Determination and Mathematical Modelling of Propylene Glycol Transport from Semisolid Vehicles

概要

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The penetration of the cosolvent and penetration enhancer propylene glycol (PG) into a multilayer membrane system was examined. Consisting of dodecanol (DD) this acceptor system was used to simulate the intercellular lipid pathway across the stratum corneum. Vehicles with 10%, 40% and 60% PG were investigated. Using a pharmacokinetic description based on Fick's first law of diffusion, the transport rate of PG was simulated. A parameter estimation was carried out to obtain a kinetic velocity parameter k_<PG> for the transport. k<PG> depends on the diffusion coefficient, the area of application, and the pathlength. The data were validated by determining confidence intervals. The extent of the penetration of PG into the lipophilic acceptor system was shown to be quantitative. The data presented are useful for further investigations to assess the solvent drag effect caused by PG penetration. The multiplayer membrane model was found to provide reasonable results with respect to accuracy and reproducibility.
公益社団法人日本薬学会の論文
1996-06-15