Studies on the Synthesis and Structure-Activity Relationships of 2-(2-Functionalized Pyrrolidin-4-ylthio)-1β-methylcarbapenems
スポンサーリンク
概要
- 論文の詳細を見る
A series of new carbapenem derivatives, which have a pyrrolidin-4-ylthio group substituted with a hydroxyalkyl or carbamoyl group at the 2' position as the C-2 side chain, have been prepared. The antibacterial activity and the stability to renal dehydropeptidase-I of these compounds were investigated, and the structure-activity relationships were studied. Among these new carbapenems, (1R, 5S, 6S)-2-[(2S, 4S)-2-{(2-hydroxy)ethylmercaptomethyl}pyrrolidin-4-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid (1a) showed the most potent and well balanced activity and was selected as a candidate for further evaluation.
- 社団法人日本薬学会の論文
- 1996-12-15
著者
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Ahn S‐k
Chong Kun Dang Corp. Seoul Kor
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LEE Hong-Woo
Research Institute, Chong Kun Dang Corp.
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KIM Eung-Nam
Research Institute, Chong Kun Dang Corp.
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SON Hoe-Joo
Research Institute, Chong Kun Dang Corp.
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AHN Soon-Kil
Research Institute, Chong Kun Dang Corp.
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CHUNG Koo-Hun
Research Institute, Chong Kun Dang Corp.
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KIM Jung-Woo
Research Institute, Chong Kun Dang Corp.
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LEE Chong-Ryoul
Research Institute, Chong Kun Dang Corp.
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Ahn Soon-kil
Research Institute Chong Kun Dang Corp.
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Kim Jung-woo
Research Institute Chong Kun Dang Corp.
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Lee H‐w
Research Institute Chong Kun Dang Corp.
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Kim Eung-nam
Research Institute Chong Kun Dang Corp.
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Lee Hong-woo
Research Institute Chong Kun Dang Corp.
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Son Hoe-joo
Research Institute Chong Kun Dang Corp.
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Lee Chong-ryoul
Research Institute Chong Kun Dang Corp.
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Chung Koo-hun
Research Institute Chong Kun Dang Corp.
関連論文
- Studies on the Synthesis and Structure-Activity Relationships of 2-(2-Functionalized Pyrrolidin-4-ylthio)-1β-methylcarbapenems
- Synthesis and Structure-activity Relationship of 2-(5-Substituted pyrrolidin-4-ylthio)-1β-carbapenems
- Studies on the Synthesis and Antibacterial Activity of New Carbamoylpyrrolidinylthio carbapenems