Synthesis of Isomelamines and Isocyanurates and Their Biological Evaluation
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概要
- 論文の詳細を見る
The reaction of cyanogen bromide (1) with primary amines (2a-p), including arylmethylamines (2l-p), gave the corresponding cyanamides (3a-p). Trimerization of 3a-p gave 1,3,5-trisubstituted 2,4,6-triiminohexahydro-1,3,5-triazines (isomelamines) (4a-p), which were treated with hydrochloric acid to give the corresponding 1,3,5-trisubstituted 2,4,6-trioxohexahydro-1,3,5-triazines (isocyanurates) (5a-c, f) and 1,3,5-trisubstituted 2-imino-4,6-dioxohexahydro-1,3,5-triazines (5b'-e'). Biological evaluation of 4a-p, 5a-c, f, and 5b'-e' was carried out, and some of these compounds showed bronchodilator and positive inotropic activities.
- 公益社団法人日本薬学会の論文
- 1996-12-15
著者
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Kamada Hitoshi
Institute For Life Suppport Technology Yamagata Technopolis Foundation
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Kamada Hitoshi
Institute For Life Support Technology
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NIWA Ryuji
Institute for Life Support Technology, Yamagata Technopolis Foundation
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Niwa Ryuji
Institute For Life Support Technology Yamagata Technopolis Foundation
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SHITARA Eiki
MECT Co.,
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HORIUCHI Jiro
MECT Co.,
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KIBUSHI Nobuyuki
MECT Co.,
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KATO Tetsuzo
MECT Co.,
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Shitara E
Inst. Microbial Chemistry Shinagawa‐ku Jpn
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Kato Tetsuzo
Mect Co.
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Horiuchi J
Mect Co.
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Kibushi Nobuyuki
Mect Co.
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