Design and Synthesis of a New 4-Oxa-8ω-11-deoxy-5,6-dihydroprostacyclin Analogue
スポンサーリンク
概要
- 論文の詳細を見る
(±)-5-[5β-(((E)-1-Octen-3-ol)-1)-2-oxabicyclo[3.3.0]octan-3-yl]-4-oxapentanoic acid (±)-(1a, b), designed as a chemically and biologically stable prostacyclin analogue, was synthesized in 15% yield overall, via the (±)-3-hydroxymethyl-5-carbethoxy-2-oxabicyclo[3.3.0]octane (4) as the key intermediate.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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FRAGA Carlos
Laboratorio de Avaliacao e Sintese de Substancias Bioativas, Departamento de Farmacos, Faculdade de
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BARREIRO Eliezer
Laboratorio de Avaliacao e Sintese de Substancias Bioativas, Departamento de Farmacos, Faculdade de
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MIRANDA Ana
Laboratorio de Avaliacao e Sintese de Substancias Bioativas, Departamento de Farmacos, Faculdade de
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Miranda Ana
Laboratorio De Avaliacao E Sintese De Substancias Bioativas (lassbio) Faculdade De Farmacia Universi
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Fraga Carlos
Laboratorio De Avaliacao E Sintese De Substancias Bioativas (lassbio) Faculdade De Farmacia Universi
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Barreiro Eliezer
Laboratorio De Avaliacao E Sintese De Substancias Bioativas (lassbio) Faculdade De Farmacia Universi
関連論文
- Antinociceptive Profile of 2,3,6-Trisubstituted Piperidine Alkaloids : 3-O-Acetyl-spectaline and Semi-synthetic Derivatives of (-)-Spectaline
- Design and Synthesis of a New 4-Oxa-8ω-11-deoxy-5,6-dihydroprostacyclin Analogue