Synthesis and Testosterone 5α-Reductase-Inhibitory Activity of 4-Aza-5α-androstane-17-carboxamide Compound with an Aromatic Moiety in the C-17 Carbamoyl Group
スポンサーリンク
概要
- 論文の詳細を見る
A series of 4-aza-5α-androstane compounds with one or two aromatic moieties in the carbamoyl group at the C-17 position were synthesized and their inhibitory activities for rat and human prostatic testosterone 5α-reductase were tested in vitro. Compounds with one aromatic moiety in the carbamoyl group showed high inhibitory activity for rat 5α-reductase, but little for human prostatic 5α-reductase. On the other hand, compounds with two aromatic moieties had potent inhibitory activities for both rat and human 5α-reductase. The structural requirements for potent inhibition for both enzymes are discussed in relation to the spatial arrangement of the C-17 carbamoyl group.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Furukawa Y
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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Furukawa Yoji
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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HORIKOSHI Hiroyoshi
Pharmacology and Molecular Biology Research Laboratories
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Kurata H
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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Kojima Koichi
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd. :(present Address)neuroscience Research La
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Saito Shinichi
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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Hamada T
Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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ISHIBASHI Koki
Medicinal Chemistry Research Laboratories Sankyo Co., Ltd.
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HAMADA Takakazu
Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd.
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KURATA Hitoshi
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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Ishibashi K
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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Hamada Takakazu
Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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Horikoshi H
Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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