Piperazinomethyl Tetralines : Synthesis and Affinities for D_1,D_2 and 5-HT_<2A> Receptors
スポンサーリンク
概要
- 論文の詳細を見る
Starting from the methyl ester of β-(bromomethyl)-γ-phenylbutyric acid and its m-fluoro derivative, we have prepared 2-[4[3-(p-fluorobenzoyl)-1-propyl]piperazin-1-ylmethyl]tetraline (QF0105B) and the corresponding 7-fluoro derivative (QF0106B). The affinities of these compounds for D_1 and D_2 dopamine and 5-HT_<2A> receptors was evaluated in vitro. The afinities of QF0105B and QF0106B for D_2 receptors are less than that of haloperidol (pK_i's for inhibition of [^3H]spiperone binding : 7.72,7.06 and 8.30,respectively) but all three compounds have similar affinities for 5-HT_<2A> receptors (pK_i'S for inhibition of [^3H]ketanserine binding : 7.70,7.36 and 7.70,respectively).
- 公益社団法人日本薬学会の論文
- 1995-07-15
著者
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Ravina E
Lahoratorio De Quimica Farmacciitica Deparhimento De Qitimica Organica Facultud De Farmacia Universi
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De Ceballos
Department Of Neuropharmacology Cajal Institute
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G-ferreiro Tomas
Department Of Pharmacology Faculty Of Pharmacy University
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Ravina Enrique
Department Of Organic Chemistry (section Of Medicinal Chemistry) School Of Pharmacy
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NEGREIRA Jesus
Department of Organic Chemistry, Laboratory of Medicinal Chemistry
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CID Jose
Department of Organic Chemistry, Laboratory of Medicinal Chemistry
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ROSA Elizabeth
Department of Pharmacology, Faculty of Pharmacy, University
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CASTRO Maria
Department of Pharmacology, University of Santiago de Compostela
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MOLDES Victor
Department of Pharmacology, University of Santiago de Compostela
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MACALLEJA Jose
Department of Pharmacology, University of Santiago de Compostela
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Cid Jose
Department Of Organic Chemistry Laboratory Of Medicinal Chemistry
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Castro Maria
Department Of Pharmacology University Of Santiago De Compostela
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Macalleja Jose
Department Of Pharmacology Faculty Of Pharmacy University
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Moldes Victor
Department Of Pharmacology University Of Santiago De Compostela
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Rosa Elizabeth
Department Of Pharmacology Faculty Of Pharmacy University
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Negreira Jesus
Department Of Organic Chemistry Laboratory Of Medicinal Chemistry
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CASTRO Maria
Department of Neurosurgery, The University of Michigan School of Medicine
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CASTRO Maria
Department of Analytical Chemistry, Annex C-3, Campus of Rabanales, University of Cordoba
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