Structure-Activity Relationship of Phenyl- and Benzoylpyrroles
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概要
- 論文の詳細を見る
Antitumor, antimicrobial, and phytotoxic activities of the marine antibiotic pentabromopseudilin (1a) and related phenyl-, benzyl- and benzoyl pyrroles were compared. All activities depended strongly on the substituent pattern, with the natural compound 1a being the most active one. As judged from model reactions, a covalent bond of nucleophiles to the pyrrole system may be involved in the inhibition of macromolecular syntheses.
- 公益社団法人日本薬学会の論文
- 1995-04-15
著者
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LAATSCH Hartmut
Institute of Organic Chemistry
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Kraemer Hans-peter
Hoechst Ag
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Laatsch H
Department Of Organic And Biomolecular Chemistry University Of Gottingen
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Laatsch Hartmut
Institut Fur Organische Und Biomolekulare Chemie Der Georg-august-universitat
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ANKE Heidrun
Institute for Biotechnology and Drug Research (IBWF)
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Anke Heidrun
Institut Fur Biotechnologie Der Universitat Kaiserslautern
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RENNEBERG Bernd
Institut fur Organische Chemie der Universitat Gottingen
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HANEFELD Ulf
Institut fur Organische Chemie der Universitat Gottingen
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KELLNER Michael
Institut fur Organische Chemie der Universitat Gottingen
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PUDLEINER Heinz
Institut fur Organische Chemie der Universitat Gottingen
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HAMPRECHT Gerhard
BASF AG
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HANEFELD Ulf
Institut für Organische und Biomolekulare Chemie der Georg-August-Universität
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