A Convenient One-Pot Synthesis of Acyclonucleosides

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概要

• 論文の詳細を見る

• Bis(trimethylsilyl)pyrimidine bases were treated directly with 1,3-dioxolane (or 2-methyl-1,3-dioxolane), chlorotrimethylsilane and a metal iodide, such as KI or NaI, in acetonitrile at room temperature to afford acylopyrimidine derivatives, including 2-thiopyrimidine derivatives, in good yields. Introduction of an acyclic chain into 2-thiopyrimidine bases, however, necessitated the use of 2 eq of the reagents.

• 1995-01-15

著者

• 高嶋 秀昭

  Mitsubishi Chemical Corporation Yokohama Research Center

• 姥澤 賢

  Mitsubishi Chemical Corporation Yokohama Research Center

• 関谷 浩一

  Mitsubishi Chemical Corporation Yokohama Research Center

• Takashima Hideaki

  Mitsubishi Chemical Corporation Yokohama Research Center

関連論文

• A Convenient One-Pot Synthesis of Acyclonucleosides

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