SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF A NOVEL ANTIFUNGAL AGENT, AZOXYBACILIN

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概要

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• A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-O^tBu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824,showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.

• 1994-08-15

著者

• 青木 裕子

  Nippon Roche Research Center

• 新間 信夫

  Nippon Roche Research Center

• 梅田 勲

  Nippon Roche Research Center

• 大和田 潤

  Nippon Roche Research Center

• 御塚 ひとみ

  Nippon Roche Research Center

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• SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF A NOVEL ANTIFUNGAL AGENT, AZOXYBACILIN
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