Synthesis and Structure-Activity Relationships of 7-[3-(1-Aminoalkyl)pyrrolidinyl]-and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone Antibacterials
スポンサーリンク
概要
- 論文の詳細を見る
A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1-pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them, 1-(S)-aminoalkyl derivatives exhibited potent antibacterial activities against gram-positive and gram-negative organisms. They had moderate lipophilicity and high aqueous solubility compared to their aminomethyl counterparts; e.g., the 3-(1-aminoethyl)-1-pyrrolidinyl compound (83) showed superior pharmacokinetic properties to its aminomethyl counterpart (6).
- 公益社団法人日本薬学会の論文
- 1994-07-15
著者
-
新子 省悟
Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd.,
-
新子 省悟
Exploratory Research Laboratories I Daiichi Pharmaceutical Co. Ltd.
-
早川 勇夫
Exploratory Laboratories I Daiichi Pharmaceutical Co. Ltd.
-
木村 陽一
Exploratory Laboratories I, Daiichi Pharmaceutical Co., Ltd.,
-
高橋 雅宜
Exploratory Laboratories I, Daiichi Pharmaceutical Co., Ltd.,
-
木村 陽一
Exploratory Laboratories I Daiichi Pharmaceutical Co. Ltd.
-
高橋 雅宜
Exploratory Laboratories I Daiichi Pharmaceutical Co. Ltd.
関連論文
- 最近のキノロン系抗菌剤の探索
- Regio- and Stereoselective Synthesis of Carbocyclic 2', 3'-Dideoxy-3'-fluoro Nucleosides as Potential Antiviral Agents
- Bicyclo [3. 3. 1] nonanes as Synthetic Intermediates. V. The Baeyer-Villiger Oxidation of Bicyclo [3. 3. 1] nonane-3,7-dione and Its Congeners
- Bicyclo [3. 3. 1]nonanes as Synthetic Intermediates. IV. Behavior of Bicyclo [3. n. 1] alkan-3-ones toward the Baeyer-Villiger Oxidation
- Synthesis and Antibacterial Activities of Optically Active Ofloxacin and Its Fluoromethyl Derivative(Medicinal Chemistry,Chemical)
- Synthesis and Structure-Activity Relationships of 7-[3-(1-Aminoalkyl)pyrrolidinyl]-and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone Antibacterials
- 最近のキノロン系抗菌剤の探索