Electrochemical Oxidation of Anti-tumor Agent, Etoposide

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概要

• 論文の詳細を見る

• As part of a search for new potent derivatives, electrochemical oxidation of etoposide (1) was carried out under controlled potential (500mV) to yield 1,2-dehydroetoposide (4), 4'-O-demethyl-1,2,3,4-tetradehydro-4-dehydroxy-podophyllotoxin (5) and 1,2,3,4-tetradehydroetoposide (6). They showed no cytotoxicity against B16-melanoma.

• 公益社団法人日本薬学会の論文
• 1993-10-15

著者

• 大沼 毅

  Bristol-myers Squibb Research Institute Bristol-myers Squibb K.k.

• 小畠 りか

  Bristol-Myers Squibb Research Institute, Ltd., Tokyo Research Center

• 小畠 りか

  Bristol-myers Squibb Research Institute Bristol-myers Squibb K.k.

関連論文

• Preparation and Antitumor Activity of 2"-O-, 3"-O- and 2", 3"-Di-O-substituted Derivatives of Etoposide
• Electrochemical Oxidation of Anti-tumor Agent, Etoposide

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