Preparation of New Nitrogen-Bridged Heterocycles. XXXIII. A New Preparative Method for Thieno[3,2-α]indolizines

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概要

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• The treatment of 2-iminothieno[3,2-α]indolizine derivatives with potassium tert-butoxide generated exclusively potassium 1-(2-cyanovinyl)indolizine-2-thiolates through the ring opening of the initially formed thiin-2-imide ions. These 2-indolizinethiolates reacted with various alkylating agents to give the corresponding S-alkylated 1-vinylindolizine derivatives, and 2-acetonylthio- and 2-phenacylthio-1-(2-cyanovinyl)indolizines of these products smoothly underwent intramolecular Michael addition under the conditions employed here to afford the corresponding 2-acetyl- and 2-aroylthieno[3,2-α]indolizines in high yields with the elimination of a methylene compound.

• 社団法人日本薬学会の論文
• 1993-10-15

著者

• 筧 昭一

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• 伊東 祐隆

  Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University

• 上田 達也

  Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University

• 高野 哲

  Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University

• 高野 哲

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• 伊東 祐隆

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• 上田 達也

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

関連論文

• Preparation of New Nitrogen-Bridged Heterocycles. XXXIII. A New Preparative Method for Thieno[3,2-α]indolizines
• Preparation of New Nitrogen-Bridged Heterocycles. XXXI. Cyclization Aptitudes of 2-Acylmethyl-thio-3-cyanoindolizines Having a Cyano or an Ester Group at the 1-Position
• Preparation of New Nitrogen-Bridged Heterocycles. XXVI. Crystal Structures of Thieno[3,2-a]-and Thieno[2,3-b]indolizine Derivatives
• Preparation of New Nitrogen-Bridged Heterocycles. XXIV. : Syntheses and Reactions of Pyrazolo[1,5-a]pyridine-2-thiols. (2)
• Preparation of New Nitrogen-Bridged Heterocycles. XXIII. : Syntheses and Reactions of Pyrazolo[1,5-a]pyridine-2-thiols. (1)
• Preparation of New Nitrogen-Bridged Heterocycles. XXII. : A New Approach to the Syntheses of Thienoindolizine Derivatives
• Preparation of New Nitrogen-Bridged Heterocycles. XIV. Further Investigation of the Desulfurization and the Rearrangement of Pyrido[1,2-d]-1,3,4-thiadiazine Intermediates(Organic,Chemical)
• Preparation of New Nitrogen-Bridged Heterocycles. XIII. : Syntheses of Some Tricyclic and Tetracyclic Indolizine Derivatives with Antiallergic Activity

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